Ames test

  • Ames test
  • A bioassay developed by Bruce N. Ames in 1974, performed on bacteria to assess the capability of environmental chemicals to cause mutations.
Abstract from DBPedia
    The Ames test is a widely employed method that uses bacteria to test whether a given chemical can cause mutations in the DNA of the test organism. More formally, it is a biological assay to assess the mutagenic potential of chemical compounds. A positive test indicates that the chemical is mutagenic and therefore may act as a carcinogen, because cancer is often linked to mutation. The test serves as a quick and convenient assay to estimate the carcinogenic potential of a compound because standard carcinogen assays on mice and rats are time-consuming (taking two to three years to complete) and expensive. However, false-positives and false-negatives are known. The procedure was described in a series of papers in the early 1970s by Bruce Ames and his group at the University of California, Berkeley.

    エームズ試験(Ames test)とは、物質の変異原性を評価するためのバイオアッセイ試験法である。カリフォルニア大学バークレー校のブルース・エイムス(Bruce N. Ames)教授らにより1970年代に開発されたため、エームズ試験の名がある。 変異原性物質には発癌性物質(イニシエーター)でもあるものが多いため、エームズ試験は発癌性予測の意味でも実施されている。ただしエームズ試験陽性物質と発癌性物質は重ならない部分も多い。